<html xmlns:ns0="http://macVmlSchemaUri"> <head> <meta http-equiv=Content-Type content="text/html; charset=unicode"> <meta name=Generator content="Microsoft Word 15 (filtered)"> <style> <!-- /* Font Definitions */ @font-face {font-family:Helvetica; panose-1:0 0 0 0 0 0 0 0 0 0;} @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4;} @font-face {font-family:"Lucida Grande"; panose-1:2 11 6 0 4 5 2 2 2 4;} @font-face {font-family:Ferdsch; panose-1:2 11 6 4 2 2 2 2 2 4;} @font-face {font-family:"0000҉0 Pro W3"; panose-1:2 11 3 0 0 0 0 0 0 0;} @font-face {font-family:"Yu Mincho"; panose-1:2 2 4 0 0 0 0 0 0 0;} @font-face {font-family:"______ Pro W3"; panose-1:2 11 6 4 2 2 2 2 2 4;} @font-face {font-family:"\@Yu Mincho";} @font-face {font-family:"\@0000҉0 Pro W3";} @font-face {font-family:"\@______ Pro W3";} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {margin:0in; margin-bottom:.0001pt; layout-grid-mode:char; font-size:10.0pt; font-family:Ferdsch;} h5 {mso-style-link:"Heading 5 Char"; margin:0in; margin-bottom:.0001pt; text-align:center; page-break-after:avoid; layout-grid-mode:char; font-size:16.5pt; font-family:"Times New Roman",serif;} p.MsoHeading9, li.MsoHeading9, div.MsoHeading9 {mso-style-link:"Heading 9 Char"; margin:0in; margin-bottom:.0001pt; text-align:center; page-break-after:avoid; layout-grid-mode:char; font-size:14.0pt; font-family:"Times New Roman",serif;} p.MsoHeader, li.MsoHeader, div.MsoHeader {mso-style-link:"Header Char"; margin:0in; margin-bottom:.0001pt; layout-grid-mode:char; font-size:10.0pt; font-family:Ferdsch;} p.MsoFooter, li.MsoFooter, div.MsoFooter {mso-style-link:"Footer Char"; margin:0in; margin-bottom:.0001pt; layout-grid-mode:char; font-size:10.0pt; font-family:Ferdsch;} a:link, span.MsoHyperlink {color:blue; text-decoration:underline;} a:visited, span.MsoHyperlinkFollowed {color:#954F72; text-decoration:underline;} p.MsoAcetate, li.MsoAcetate, div.MsoAcetate {mso-style-link:"Balloon Text Char"; margin:0in; margin-bottom:.0001pt; layout-grid-mode:char; font-size:9.0pt; font-family:"Lucida Grande",sans-serif;} span.Heading5Char {mso-style-name:"Heading 5 Char"; mso-style-link:"Heading 5"; font-family:"Times New Roman",serif; layout-grid-mode:line; font-weight:bold;} p.msonormal0, li.msonormal0, div.msonormal0 {mso-style-name:msonormal; margin-right:0in; margin-left:0in; font-size:12.0pt; font-family:"Times New Roman",serif;} span.Heading9Char {mso-style-name:"Heading 9 Char"; mso-style-link:"Heading 9"; font-family:"Times New Roman",serif; layout-grid-mode:line;} span.BalloonTextChar {mso-style-name:"Balloon Text Char"; mso-style-link:"Balloon Text"; font-family:"Lucida Grande",sans-serif;} p.Body, li.Body, div.Body {mso-style-name:Body; margin:0in; margin-bottom:.0001pt; font-size:12.0pt; font-family:Helvetica; color:black;} span.HeaderChar {mso-style-name:"Header Char"; mso-style-link:Header; font-family:Ferdsch;} span.FooterChar {mso-style-name:"Footer Char"; mso-style-link:Footer; font-family:Ferdsch;} span.Emphasis1 {mso-style-name:Emphasis1; font-family:"Times New Roman",serif; font-weight:bold; font-style:normal;} .MsoChpDefault {font-size:10.0pt; font-family:"Calibri",sans-serif;} /* Page Definitions */ @page WordSection1 {size:8.5in 11.0in; margin:1.0in 1.25in 1.0in 1.25in;} div.WordSection1 {page:WordSection1;} /* List Definitions */ ol {margin-bottom:0in;} ul {margin-bottom:0in;} --> </style> </head> <body bgcolor=white lang=EN-US link=blue vlink="#954F72"> <div class=WordSection1> <p class=MsoHeading9><span style='font-size:12.0pt'>Curriculum Vitae</span></p> <h5><span style='font-size:12.0pt'>Axel Thomas Brunger</span></h5> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>TITLE:</span></b></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>Professor of Molecular and Cellular Physiology,</span></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>Neurology and Neurological Sciences, </span></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>Structural Biology (by Courtesy), and Photon Science</span></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>Investigator, Howard Hughes Medical Institute </span></p> <p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>ADDRESS:</span></b></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>J. H. Clark Center, Room E300-C, 318 Campus Drive, Stanford, CA 94305-5432</span></p> <p class=MsoNormal style='margin-left:.2in'><span lang=FR style='font-size: 12.0pt;font-family:"Times New Roman",serif'>email: </span><span class=MsoHyperlink><span lang=DE style='font-size:12.0pt;font-family:"Times New Roman",serif'><a href="mailto:brunger@stanford.edu">brunger@stanford.edu</a></span></span><span lang=FR style='font-size:12.0pt;font-family:"Times New Roman",serif'>, web&nbsp;: <span class=MsoHyperlink><a href="http://atbweb.stanford.edu">http://atbweb.stanford.edu</a></span></span></p> <p class=MsoNormal style='margin-left:.2in'><span lang=FR style='font-size: 12.0pt;font-family:"Times New Roman",serif'>phone: 650-736-1031</span></p> <p class=MsoNormal style='margin-left:.2in'><span lang=FR style='font-size: 12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>BORN:</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> November 25, 1956, Leipzig, Germany </span></p> <p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>CITIZENSHIP:</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> USA </span></p> <p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>EDUCATION:</span></b></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1977</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Vordiplom in Physics and Mathematics, Univ. of Hamburg.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1980</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Diplom in Physics, Univ. of Hamburg.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1982</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Ph.D. in Biophysics, Tech. Univ. of Munich, Germany.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1980 </span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'>Graduate Student, MPI for Biophysical Chemistry, with Klaus Schulten. </span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1980-1982</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Graduate Student, Tech. Univ. of Munich, with Klaus Schulten.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1982-1983</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Postdoc. Fellow, Chemistry Dept., Harvard Univ., with Martin Karplus.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1984</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Postdoc. Fellow, MPI for Biochemistry, with Dieter Oesterhelt, Robert Huber.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1985-1987</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Research Assoc., Chemistry Dept., Harvard Univ., with Martin Karplus.</span></p> <p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>POSITIONS:</span></b></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1995-present</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Investigator, Howard Hughes Medical Institute.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2000-present </span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Professor, Molecular and Cellular Physiology, Stanford Univ.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2013-2017</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Chair, Dept. of Molecular and Cellular Physiology, Stanford Univ.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1993-2000</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Professor, Molecular Biophysics &amp; Biochemistry, Yale Univ.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1992-1995</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Associate Investigator, Howard Hughes Medical Institute.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1991-1993</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Associate Professor, Molecular Biophysics &amp; Biochemistry, Yale Univ.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1987-1992</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Assistant Investigator, Howard Hughes Medical Institute.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1987-1991</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Assistant Professor, Molecular Biophysics &amp; Biochemistry, Yale Univ.</span></p> <p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>HONORS:</span></b></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2016</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Trueblood Award, American Crystallographic Association.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2014</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Bernard Katz Award, Exocytosis &amp; Endocytosis Group, Biophysical Society.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2014</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Carl Hermann Medal of the German Crystallographic Society (DGK).</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2011</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> DeLano Award, American Society for Biochemistry and Molecular Biology.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2012</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> HHMI Collaborative Innovation Award.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2011-2021</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Merit Award, NIMH.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2005</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Member, National Academy of Sciences.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2004</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Nobel Symposium Speaker, Stockholm, Sweden.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2003</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Gregori Aminoff Prize, The Royal Swedish Academy of Sciences.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1995</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Rntgen Prize in Biosciences, University of Wrzburg, Germany.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1982-1983</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> NATO Postdoctoral Fellowship.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1976-1982</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Studienstiftung des Deutschen Volkes Fellowship.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>1975</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> National Mathematics Competition Prize, Germany.</span></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>NAMED LECTURES:</span></b></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> 2018 </span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Robert Whitney Newcomb Memorial Lecture, NIH.</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> 2018 </span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Balzan Lecture, Gttingen, Germany.<b> </b></span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> 2018 </span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>BSA Distinguished Lecture, Brookhaven National Laboratory. </span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2016 </span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif;color:black'>Francis O Schmitt Lecture, MIT Department of Biology.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2014</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Bruker Lecture, IYCr2014 Innsbruck Symposium, Innsbruck.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2014</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Honorary Professor, Xi an Yiaotong University, Xi an.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2013</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Sir John Kendrew Lecture, Weizmann Institute.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2009</span></b><span style='font-size: 12.0pt;font-family:"Times New Roman",serif'> Paul Sigler Lecture, Yale University.</span></p> <p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>EDITORIAL POSITIONS:</span></b></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2009-2015 </span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Member of the Editorial Board for <i>Biophysical Journal.</i></span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2011-present </span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Member of the Editorial Board for <i>Proc. Natl. Acad. Sci. USA</i>.</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>2012-present</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'> Member of the Board of Reviewing Editors for <i>eLife</i>.</span></p> <p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>MAJOR RESEARCH INTERESTS:</span></b></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>Molecular mechanisms of neurotransmission and membrane fusion.</span></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>Computational methods for structural biology.</span></p> <p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>KEY PUBLICATIONS (OUT OF OVER 290)</span></b></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Q.Zhou, P.Zhou, A.L.Wang, D.Wu, M.Zhao, T.C.Sudhof, <b>A.T.Brunger</b>. The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. <i>Nature</i> <b>548</b>, 420-425 (2017).</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>Y.Lai, U.B.Choi, J.Leitz, H.J.Rhee, C.Lee, B.Altas, M.Zhao, R.A.Pfuetzner, A.L.Wang, N.Brose, J.Rhee, <b>A.T.Brunger</b>.Molecular mechanisms of synaptic vesicle priming by Munc13 and Munc18. <i>Neuron</i> <b>95</b>, 591607 (2017). </span></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>Q.Zhou, Y.Lai, T.Bacaj, M.Zhao, A.Y.Lyubimov, M.Uervirojnangkoorn, O.B.Zeldin, A.S.Brewster, N.K.Sauter, A.E.Cohen, S.M.Soltis, R.Alonso-Mori, M.Chollet, H.T.Lemke, R.A.Pfuetzner, U.B.Choi, W.I.Weis, J.Diao, T.C.Sudhof, <b>A.T.Brunger</b>, Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. <i>Nature</i> <b>525</b>, 62-67 (2015). </span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>&nbsp;</span></b></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>M.Zhao, S.Wu, Q.Zhou, S.Vivona, D.J.Cipriano, Y.Cheng, <b>A.T.Brunger</b>. Mechanistic insights into the recycling machine of the SNARE complex. <i>Nature</i> <b>518</b>, 61-67 (2015).</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>&nbsp;</span></b></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>Y.Lai, J.Diao, D.J.Cipriano, Y.Zhang, R.A.Pfuetzner, M.S.Padolina, <b>A.T.Brunger</b>. Complexin inhibits spontaneous release and synchronizes Ca<sup>2+</sup>-triggered synaptic vesicle fusion by distinct mechanisms. <i>eLife</i> <b>3</b>, e03756 (2014).</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>&nbsp;</span></b></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>J.Diao, J.Burre, S.Vivona, D.J.Cipriano, M.Sharma, M.Kyoung, T.C.Sudhof, <b>A.T.Brunger</b>. Native alpha-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2. <i>eLife 2</i>, e00592 (2013).</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>&nbsp;</span></b></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>J.Diao, P.Grob, D.J.Cipriano, M.Kyoung, Y.Zhang, S.Shah, A.Nguyen, M.Padolina, A.Srivastava, M.Vrljic, A.Shah, E.Nogales, S.Chu, <b>A.T.Brunger</b>. Synaptic proteins promote calcium-triggered fusion from point contract to full fusion. <i>eLife</i> <b>1</b>, e00109 (2012). </span></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal style='margin-left:.2in'><span lang=DE style='font-size: 12.0pt;font-family:"Times New Roman",serif'>M. Kyoung, A. Srivastava, Y. Zhang, J. Diao, M. Vrljic, P. Grob, E. Nogales, S. Chu, <b>A.T. Brunger</b>. In vitro system capable of differentiating fast calcium-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release. <i>Proc. Natl. Acad. Sci. USA</i> <b>108</b>, E304-E313 (2011).</span></p> <p class=MsoNormal style='margin-left:.2in'><b><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>&nbsp;</span></b></p> <p class=MsoNormal style='margin-left:.2in'><span style='font-size:12.0pt; font-family:"Times New Roman",serif'>G.F.Schroeder, M.Levitt, <b>A.T.Brunger</b>, Super-resolution biomolecular crystallography with low-resolution data. <i>Nature</i> <b>464</b>, 1218-1222 (2010).</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>M.A.Breidenbach, <b>A.T.Brunger</b>, Substrate recognition strategy for botulinum neurotoxin serotype A, <i>Nature</i> <b>432</b> 925-929 (2004).</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span lang=DE style='font-size:12.0pt;font-family:"Times New Roman",serif'>K. Weninger, M.E. Bowen, S. Chu, </span><span class=Emphasis1><span lang=DE style='font-size:12.0pt'>A.T. Brunger</span></span><span lang=DE style='font-size:12.0pt;font-family:"Times New Roman",serif'>. Single molecule studies of SNARE complex assembly reveal parallel and anti-parallel configurations. <i>Proc. Natl. Acad. Sci. USA </i><b>100</b>, 14800-14805 (2003). </span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>B. DeLaBarre and <b>A.T. Brunger</b>, Complete Structure of p97/Valosin-Containing Protein Reveals Communication Between Nucleotide Domains, <i>Nature Structural Biology </i><b>10</b>, 856-863 (2003).</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>R.B.Sutton, D.Fasshauer, R.Jahn, <b>A.T.Brunger</b>. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. <i>Nature</i> <b>395</b>, 347-353 (1998).</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>A.T.Brunger</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>, P. D.Adams, G. M.Clore, W.L.DeLano, P.Gros, R.W.Grosse-Kunstleve, J.-S.Jiang, J.Kuszewski, M.Nilges, N.S.Pannu, R.J.Read, L.M.Rice, T.Simonson, G.L.Warren, Crystallography &amp; NMR system (CNS): A new software system for macromolecular structure determination, <i>Acta Cryst. D</i> <b>54</b>, 905-921 (1998).</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>F. T. Burling, W. I. Weis, K. M. Flaherty, and <b>A. T. Brunger</b>, Direct observation of protein solvation and discrete disorder with experimental crystallographic phases, <i>Science</i> <b>271</b>, 72-77 (1996).<br> <br> </span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>A.T.Brunger</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>, The free <i>R</i> value: a novel statistical quantity for assessing the accuracy of crystal structures, <i>Nature</i> <b>355</b>, 472-474 (1992).</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>&nbsp;</span></p> <p class=MsoNormal style='margin-left:.2in;layout-grid-mode:both;text-autospace: none'><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>A.T.Brunger</span></b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>, J.Kuriyan, M.Karplus, Crystallographic <i>R</i> factor refinement by molecular dynamics, <i>Science</i> <b>235</b>, 458-460 (1987).</span></p> </div> </body> </html>