Research Highlights

Our laboratory studies the molecular mechanisms of neurotransmitter release, and how these mechanisms relate to physiological function.


Calcium triggering: SNARE/complexin/synaptotagmin complex

Disassembly of the SNARE complex by NSF/SNAP

Key Publications

K.I. White, M. Zhao, U.B. Choi, R.A. Pfuetzner, A.T. Brunger. Structural principles of SNARE complex recognition by the AAA+ protein NSF. eLife 7, e38888. 10.7554/eLife.38888 (2018).

U.B. Choi, M. Zhao, K.I. White, R.A. Pfuetzner, L. Esquivies, Q. Zhou, A.T. Brunger (2018). NSF-mediated disassembly of on and off-pathway SNARE complexes and inhibition by complexin. eLife 7, e36497, 10.7554/eLife.36497 (2018).

A.T.Brunger, U.B. Choi, Y. Lai, J. Leitz, Q. Zhou. Molecular Mechanisms of Fast Neurotransmitter Release. Annu. Rev. Biophys. 47, 469-497 (2018).

A.T.Brunger, J. Leitz, Q. Zhou, U.B. Choi, Y. Lai. Ca2+-triggered synaptic vesicle fusion initiated by release of inhibition. Trends in Cell Biology 28, 631-645 (2018).

Q. Zhou, P. Zhou, A.L. Wang, D. Wu, M. Zhao, T.C. Sudhof, A.T. Brunger. The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature 548, 420-425 (2017).

Y. Lai, U.B. Choi, J. Leitz, H.J. Rhee, C. Lee, B. Altas, M. Zhao, R.A. Pfuetzner, A.L. Wang, N. Brose, J. Rhee, A.T. Brunger. Molecular mechanisms of synaptic vesicle priming by Munc13 and Munc18. Neuron 95, 591-607 (2017).

P. Gipson, Y. Fukuda, R. Danev, Y. Lai, D.-H. Chen, W. Baumeister, A.T. Brunger. Morphologies of synaptic protein membrane fusion interfaces. Proc. Natl. Acad. Sci. USA 114, 9110-9115 (2017).